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KMID : 0613820220320030256
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Journal of Life Science
2022 Volume.32 No. 3 p.256 ~ p.262
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Function of 27-Hydroxycholesterol in Various Tissues and Diseases
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Shim Wan-Seog
Lee Chan-Hee
Azamov Bakhovuddin
Kim Koan-Hoi
Lee Dong-Jun
Song Park-Yong
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Abstract
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Oxysterols are oxygenated metabolites of cholesterol generated by serial enzymatic reactions during bile acid synthesis. Similar to cholesterol, oxysterols move rapidly to the intracellular region and modulate various cellular processes, such as immune cell responses, lipid metabolism, and cholesterol homeostasis. Different nuclear transcription factors, such as glucocorticoid, estrogen, and liver X receptors, can be modulated by oxysterols in multiple tissues. The most abundant oxysterol, 27-hydroxycholesterol (27-OHC), is a well-known selective modulator that can either activate or suppress estrogen receptor activity in a tissue-specific manner. The contribution of 27-OHC in atherosclerosis development is apparent because a large amount of it is found in atherosclerotic plaques, accelerating the transformation of macrophages into foam cells that uptake extracellular modified lipids. According to previous studies, however, there are opposing opinions about how 27-OHC affects lipid and cholesterol metabolism in metabolic organs, including the liver and adipose tissue. In particular, the effects of 27-OHC on lipid metabolism are entirely different between in vitro and in vivo conditions, suggesting that understanding the physiology of this oxysterol requires a sophisticated approach. This review summarizes the potential effects of 27-OHC in atherosclerosis and metabolic syndromes with a special discussion of its role in metabolic tissues.
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KEYWORD
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Adipose tissue, atherosclerosis, Estrogen receptor (ER), 27-hydroxycholesterol (27-OHC), liver
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